Sebadoh () is an American indie rock band formed in 1986 in Northampton, Massachusetts, by Eric Gaffney and Lou Barlow, with multi-instrumentalist Jason Loewenstein completing the line-up in 1989. Barlow co-created Sebadoh as an outlet for his songwriting when J. Mascis gradually took over creative control of Dinosaur Jr., in which Barlow plays bass guitar.

Along with such bands as Pavement, Beat Happening and Guided by Voices, Sebadoh helped pioneer a lo-fi style of indie rock characterized by low-fidelity recording techniques that employed four-track cassette tape machines. The band's early output, such as The Freed Man and Weed Forestin' (both released 1990), as well as Sebadoh III (1991), was typical of this style. Following the release of Bubble & Scrape in 1993, Gaffney left the band. His replacement and erstwhile stand-in, Bob Fay, appeared on Bakesale (1994) and Harmacy (1996), but was fired before the sessions for the band's major label release The Sebadoh (1999), featuring drummer Russ Pollard.

The band then went on a 14-year recording hiatus, during which time members pursued other projects while occasionally touring as Sebadoh. The group, fronted by Barlow and now featuring drummer Bob D'Amico, returned in 2012 with the Secret EP and, in 2013, a full-length album titled Defend Yourself, which were both self-recorded. The album Act Surprised followed in 2019.