"Disease" is a song by American singer-songwriter Lady Gaga. It was released on October 25, 2024, through Interscope Records, as the lead single from Gaga's upcoming eighth studio album, Mayhem. She wrote and produced the song with Andrew Watt and Cirkut, while Michael Polansky provided additional songwriting. Musically, "Disease" is a dark pop, electropop, dance-pop, synth-pop, and EDM song. The melodramatic lyrics of the song discuss love's ability to heal a lover's disease.

"Disease" received positive reviews from music critics, who praised its production and Gaga's vocals, although some found the lyrics uncreative. It reached number 14 on the Billboard Global 200 chart and the top 10 in Greece, San Marino, the Commonwealth of Independent States, and the United Kingdom; top 20 in Ireland and Latvia; and top 30 in Brazil, Canada, Lithuania, the Netherlands, Portugal, Switzerland, and the United States. The song's music video, directed by Tanu Muino, was released on October 29, 2024. It features Gaga facing different versions of herself and trying to control her personified fears.