"Run This Town" is a song by American rapper Jay-Z featuring Barbadian singer Rihanna and fellow American rapper Kanye West. Released on July 24, 2009, it was written by the artists alongside Athanasios Alatas, Jeff Bhasker, and No I.D., the latter producing it with West. "Run This Town" was released as the second single from Jay-Z's eleventh studio album, The Blueprint 3.

The song was a commercial success, reaching number 2 on the Billboard Hot 100 and topping the charts in the United Kingdom. It additionally made top ten chartings in ten other countries including in Australia, Norway, Sweden, and Switzerland.

"Run This Town" won Best Rap Song and Best Rap/Sung Collaboration at the 52nd Annual Grammy Awards. The song's accompanying music video, directed by Anthony Mandler, depicts the trio in a post-apocalyptic environment, featuring scenes involving angry protesters surrounding them. "Run This Town" was performed by Jay-Z, West, and Rihanna on the series premiere of The Jay Leno Show in the United States.