Paul Shaffer and the World's Most Dangerous Band is an American musical ensemble led by Paul Shaffer. It was David Letterman's house band for 33 years.

The band formed in 1982 to serve as house band for NBC's Late Night with David Letterman. When Letterman moved to CBS and began hosting the Late Show with David Letterman in 1993, the band added a horn section and second guitarist, renaming itself (due to an intellectual property dispute with NBC) the CBS Orchestra, a name that lasted until Letterman left the Late Show in 2015. After a two-year hiatus, in 2017, the band was revived by Shaffer using its original name and released an album titled Paul Shaffer & The World's Most Dangerous Band, followed by a tour.