Patti Ann LuPone (born April 21, 1949) is an American actress and singer best known for her work in musical theater. After starting her professional career with The Acting Company in 1972 she soon gained acclaim for her leading performances on the Broadway and West End stage. Known for playing bold, resilient women on stage, she has won three Tony Awards, two Olivier Awards, and two Grammy Awards, and was a 2006 inductee to the American Theater Hall of Fame.

She made her Broadway debut in Three Sisters in 1973. She went on to receive three Tony Awards: two for Best Actress in a Musical for her roles as Eva Perón in Tim Rice and Andrew Lloyd Webber's Evita (1980), and Rose in Gypsy (2008) and one for Best Featured Actress in a Musical for playing Joanne in the Stephen Sondheim revival Company (2022). She was Tony-nominated for The Robber Bridegroom (1975), Anything Goes (1988), Sweeney Todd: The Demon Barber of Fleet Street (2006), Women on the Verge of a Nervous Breakdown (2010), and War Paint (2017).

For her performances on the West End stage she received two Laurence Olivier Awards: one for Best Actress in a Musical for her performances as Fantine in the original London cast of Les Misérables and Moll in The Cradle Will Rock in 1985, and the second for Best Actress in a Supporting Role in a Musical for Company in 2019. She was nominated for her role as Norma Desmond in Sunset Boulevard in 1993. She has two Grammy Awards for the recording of the 2007 Los Angeles Opera production of Rise and Fall of the City of Mahagonny.

On television, she starred in the drama series Life Goes On (1989–1993) and received Emmy Award nominations for the TV movie The Song Spinner (1995) and her guest role in the sitcom Frasier (1998). She appeared in three Ryan Murphy series: American Horror Story (2013–2014, 2022), Pose (2019), and Hollywood (2020). Additional television credits include Penny Dreadful (2014–2016), Crazy Ex-Girlfriend (2017), and Agatha All Along (2024). LuPone's film roles include 1941 (1979), Witness (1985), Driving Miss Daisy (1989), Summer of Sam (1999), State and Main (2000), and Beau Is Afraid (2023).