Ana Karylle Padilla Tatlonghari-Yuzon (born March 22, 1981), known mononymously as Karylle, is a Filipino singer and actress. Having achieved mainstream success across stage, screen, and music, her accolades include four Awit Awards, an Asian Television Award, two MTV Pilipinas Music Award, a New York Festivals International TV and Film Award, and a Star Award for Television, including nominations from Monte Carlo Festival, Aliw Awards and Golden Screen Awards.

Born and raised in Manila, Philippines, Karylle first ventured into theater musical in 2000 and played several supporting roles in film and television. She rose to stardom after playing Sanggre Alena in the drama fantasy series Encantadia (2005). She reprised her role in the succeeding sequels and crossover such as Etheria (2005), Mulawin: The Movie (2005) and Encantadia: Pag-ibig Hanggang Wakas (2006). It was followed by the theatrical release of the blockbuster film Moments of Love (2006), which she starred with Iza Calzado and Dingdong Dantes. She returned to stage and appeared in two major productions: Cat in the Hat (2007) and West Side Story (2008), garnering praises from the critics. Following her transfer to ABS-CBN, she made several appearances in television shows such as Nasaan Ka Maruja? (2009) and Dahil May Isang Ikaw (2009), which earned a nomination at the International Emmy Awards.

In 2010, she played a supporting role in the horror film Dalaw and became one of the mainstay host of the long-running noontime show It's Showtime the following year. She was cast as one of the lead in the Singaporean TV series The Kitchen Musical, earning her a bronze medal for "Best Performance" at the New York Festivals and a "Best Actress" nomination at the Monte Carlo Festival. On screen, she appeared in several international productions such as Point of Entry (2012) and P.I. (2017), as well as in the fantasy film Mystified (2019), which earned a nomination at the Asian Academy Creative Awards. On theaters, she appeared in more stage productions in the following years including Rodgers and Rama Hari (2012), Rodgers and Hammerstein's Cinderella (2013), Carousel (2022) and The Sound of Music (2023) among others.

As a recording artist, Karylle has released six studio albums since 2001. According to PARI, her most successful releases include the platinum-sellers Time for Letting Go (2009), Roadtrip (2011), and the gold-certified albums Time to Shine (2001) and K (2013). The song she co-wrote with Jerome Hughes, Pabigyan Ng Puso, won "Best Original Song" at the 30th Metro Manila Film Festival for the movie Mano Po III: My Love. Her musical work have earned her nominations from Asian Television Awards, Awit Awards and Star Awards for Music. Philanthropically, she has been active in supporting the Philippine Animal Welfare Society (PAWS) and charity organizations like White Cross Orphanage and ChildHaus.