Francesco Onofrio Manfredini (22 June 1684 – 6 October 1762) was an Italian Baroque composer, violinist, and church musician.

He was born at Pistoia to a trombonist. In Bologna, then a part of the Papal States, he studied violin with Giuseppe Torelli, a leading figure in the development of the concerto grosso. Manfredini also took instruction in composition from Giacomo Antonio Perti, maestro di cappella of the Basilica of San Petronio from 1696 when the orchestra was temporarily disbanded.

Much of his music is presumed to have been destroyed after his death; only 43 published works and a handful of manuscripts are known. To quote his Naxos biography, "His groups of Concerti Grossi and Sinfonias show a highly accomplished composer, well versed in the mainstream Italian school of composition".