Depapepe (デパペペ) is a music group originating from Japan. The acoustic guitar duo is composed of Takuya Miura (born 5 April 1983) and Yoshinari Tokuoka (born on 15 July 1977), who formed in 2002.

They made their major debut in 2005 with their album "Let's Go!!!", which generated sales figures of about 100,000 and ranked within the top 10 of Oricon's Instrumental Artist Debut Chart. Before that, they had released three indie albums.

The name itself comes from the combination of both short names of the band members, by combining the Japanese word for overbite, 'deppa', and the name of Tokuoka's previous band 'DERUPEPE'. Contrary to a popular rumour circulating among their fans, the two guitarists are not brothers. In their 2002 formation the pair joined with the Sony Music. They worked on insert songs for anime television series Honey and Clover.