Bone Thugs-n-Harmony (formerly known as B.O.N.E. Enterpri$e and also referred to as Bone Thugs) is an American hip hop group consisting of rappers Bizzy Bone, Wish Bone, Layzie Bone, Krayzie Bone, and Flesh-n-Bone. Formed in 1991 in Cleveland, Ohio, the group signed with American rapper Eazy-E's Ruthless Records in late 1993 and made their debut with the EP Creepin on ah Come Up the following year. The EP featured their breakout single "Thuggish Ruggish Bone". In 1995, they released their second album, E. 1999 Eternal, which included the hit singles "1st of tha Month" and "East 1999". Their song "Tha Crossroads", a tribute to their recently deceased mentor Eazy-E, earned them a Grammy Award in 1997.

The group's third album, The Art of War, was released in 1997. In 2000, their album BTNHResurrection achieved platinum status in the United States within a month of its release, whereas their 2002 album, Thug World Order, saw more moderate success, attaining platinum certification and peaking at No. 3 on the Top R&B/Hip-Hop Albums chart. After this release, the group took a hiatus from their label and subsequently released their sixth studio album, Thug Stories, independently in 2006. In 2007, they returned with a major-label release, Strength & Loyalty, through American producer Swizz Beatz's label, Full Surface Records, in partnership with Interscope Records. Bone Thugs-n-Harmony followed this with their 2010 album, Uni5: The World's Enemy, released under their own label, BTNH Worldwide, with distribution provided by Warner Bros..

Krayzie Bone and Wish Bone briefly parted ways with the group in April 2011 to focus on their independent label, The Life Entertainment. Both members, however, soon reunited with the group.

In August 2013, Layzie Bone also announced a temporary departure to concentrate on his independent label, Harmony Howse Entertainment. He too rejoined the group shortly thereafter.

In the same month, BTNH signed a new deal with eOne Music (formerly known as Koch Records), with whom they had previously collaborated for the release of Thug Stories in 2006.