Arcángel & De la Ghetto are an American reggaeton duo, consisting of Austin "Arcángel" Santos and Rafael "De la Ghetto" Castillo.

Arcángel and De la Ghetto duo began when they met in a studio in San Juan, Puerto Rico. After many hits and shows, they decided to break up the duo and pursue their talents as solo artists. They still make songs together on occasion but are no longer a duo. After launching his career and gaining notability, De la Ghetto collaborated with J Balvin, Reykon, Yelsid, Zion, Daddy Yankee, Héctor el Father, Jowell & Randy, Don Omar, Tito El Bambino, Ivy Queen, Yaga & Mackie, Tego Calderón, Ñejo & Dalmata, Alexis & Fido, and Julio Voltio, among others. De la Ghetto became known in 2005 with the single "Ven Pégate", a duet with Arcángel on the reggaeton compilation Sangre Nueva, which opened doors allowing him to participate in later reggaeton compilation albums.