Brothers and Sisters is the fourth studio album by American rock band The Allman Brothers Band. Co-produced by Johnny Sandlin and the band, the album was released in August 1973 in the United States, by Capricorn Records. Following the death of group leader Duane Allman in 1971, the Allman Brothers Band released Eat a Peach (1972), a hybrid studio/live album that became their biggest-selling album to date. Afterwards, the group purchased a farm in Juliette, Georgia, to become a "group hangout". However, bassist Berry Oakley was visibly suffering from the death of Duane, excessively drinking and consuming drugs. In November 1972, after nearly a year of severe depression, Oakley was killed in a motorcycle accident (not dissimilar from Duane's), making it the last album on which he played.

The band carried on, adding new members Chuck Leavell on piano and Lamar Williams on bass. Brothers and Sisters was largely recorded over a period of three months at Capricorn Sound Studios in Macon, Georgia. Lead guitarist Dickey Betts assumed the role of band leader, and many of his compositions reflected a more country-inspired sound. Session guitarists Les Dudek and Tommy Talton sat in on several songs. The album was being produced at the same time as vocalist/organist Gregg Allman's solo debut, Laid Back, and features many of the same musicians and engineers. The front album cover features a photograph of Vaylor Trucks, the son of drummer Butch Trucks and his wife Linda. The back cover features a photograph of Brittany Oakley, the daughter of Berry Oakley and his wife, Linda.

The album represented the Allmans' commercial peak: it has sold over seven million copies worldwide, landing it at the time atop of the Top 200 Pop Albums for five weeks. "Ramblin' Man" became the band's first and only Top-10 hit single, peaking at number two on the Billboard Hot 100 in 1973. The album was followed by a tour of arenas and stadiums, but drug problems, strained friendships, and miscommunications marred relationships between group members during this time.