Mouth Silence is the second mashup mixtape by American musician and comedian Neil Cicierega. Following the format of his previous release, Mouth Sounds, the mixtape is composed of mashups and remixes of popular songs from the 1980s, 1990s and 2000s.

Unlike Mouth Sounds, which used the song "All Star" by Smash Mouth as a recurring element, Mouth Silence relegates said song to Easter eggs.

A third installment, Mouth Moods, was released in 2017, and a fourth installment, Mouth Dreams, in 2020.

Although Mouth Silence is the second mixtape released in the series, according to Cicierega, it is a prequel to Mouth Sounds. It is, jokingly, also considered a "squeakquel" to Mouth Moods and a "shriekquel" to Mouth Dreams.

Several tracks feature original instrumental work by Cicierega, and the instrumental to "Space Monkey Mafia" is entirely original.