The Resistance is the fifth studio album by the English rock band Muse, released on 11 September 2009 through Warner Bros. Records and Muse's Helium-3 imprint. It was self-produced and recorded from September 2008 to May 2009 at Studio Bellini in Lake Como, Italy. It mixes rock with orchestral and electronic music, with lyrics influenced by politics and more oppressive subjects. It includes a three-part, 13-minute long symphony piece, "Exogenesis".

The album was promoted with the singles "Uprising", "Undisclosed Desires", and "Resistance". "Exogenesis: Symphony" was released on vinyl for Record Store Day. The Resistance Tour comprised 30 performances.

The Resistance received generally positive reviews; critics praised its concept, instrumentation, influences and Bellamy's vocals, although some found it overblown and clichéd. It won the Grammy Award for Best Rock Album at the 53rd Annual Grammy Awards.

The Resistance is Muse's most successful album, with more than five million copies worldwide. It reached number one in 19 countries and the top five in the United States and several others. It was certified platinum in countries including the UK and US.