Origin of Symmetry is the second studio album by English rock band Muse, released on 18 June 2001 through Taste Media. It was produced by John Leckie, who produced Muse's debut album, Showbiz (1999), and David Bottrill.

Origin of Symmetry is considered Muse’s breakthrough album. It reached number three on the UK Albums Chart and was certified platinum. Four singles were released: "Plug In Baby", "New Born", "Bliss", and "Hyper Music" / "Feeling Good". It was their first album to chart in the U.S. As of 2018, Origin of Symmetry had sold more than two million copies worldwide. It received mostly positive reviews, with critics praising its blend of rock and classical music. It has since been named one of the greatest rock albums of the 2000s by several publications.

For the album's 20th anniversary in 2021, Muse released a remixed and remastered version, Origin of Symmetry: XX Anniversary RemiXX.