Spottiswoode & His Enemies are a New York based rock band. Fronted by Jonathan Spottiswoode, who also writes most of the band's music, the group has an eclectic and hard to describe sound, with songs ranging from rock to folk to jazz and even gospel. Several of the band's members first played together in Washington DC bands The Oxymorons and the now-defunct The Zimmermans.

Although far from "mainstream", the band has become well known within the New York music scene during its 20+ years, regularly playing venues such as Joe's Pub and touring the East coast of the United States. The band also recently played in a Bob Dylan tribute at Avery Fisher Hall

In an NPR interview, Jonathan Spottiswoode made this comment on the paradox of being a member of a well loved band but still having to struggle financially in the harsh environment of the modern music industry: "Maybe there was an illusion that was created in the '50s and '60s and '70s where there were all these huge bands making tons of money and there still are a few. But I think maybe the old-fashioned way, where you just — you're an itinerant musician and you depended on the kindness of strangers is — maybe that's the path again these days as things kind of implode."